We think of the Pineal Gland, and its major hormone, Melatonin, as the primary coordinator of our sleep-wake cycle.  Melatonin is also a cardiac-friendly hormone, with antioxidant, anti-hypertensive, and anti-platelet effects (MI risk is lowest at 2 AM and highest at 9 AM).  A role of the Pineal gland and Melatonin in aging and senescence is also appreciated.  As we age, we make less Melatonin; our body slows down, organ system dysfunction develops, and we make less Melatonin, and so on.  A role for Melatonin in the regulation of energy production and tissue calcification has been proposed:  When Melatonin is plentiful, it is easy to incorporate phosphorus into ATP, and cellular energy is plentiful.  When Melatonin is in short supply, ATP production is blunted.  The phosphorus will then be incorporated into calcium pyrophosphate, and the mitochondria will begin to calcify.  This process occurs first in energy intensive organs, such as the heart, the kidney, and the pineal gland itself.  As the pineal begins to calcify, its output of Melatonin falls off further, so pineal and extra-pineal calcification will progress.  The Pineal gland appears to be the first organ to calcify in man – the beginning of the end.  The Pineal gland dysfunction → Melatonin deficiency → impaired energy production → cellular calcification hypothesis follows the correct time line, but it leaves out the all-important first step.

With the knowledge that N. sanguineum is present in kidney stones, PKD cyst fluid and tissue, and dental pulp stones, Hjelle looked for the presence of Nanobacterial antigen in human pineal calcifications, called acervuli or “brain sand”.  Following EDTA pre-treatment, all acervuli specimens reacted (100% positive) with NB 8/0 monoclonal antibody to N. sanguineum (the same monoclonal antibody used in the PKD study, developed by Kajander and Ciftcioglu).  N. sanguineum fixes calcium and phosphorus, producing pathological calcification in the tissues affected, and N. sanguineum is clearly present in the Pineal Gland.  When Nanobacteria are injected into rabbits, they can be recovered from the urine within 15 minutes, and from the Cerebrospinal Fluid at one year.  Nanobacteremia and Nanobacteriuria are common in humans; the bugs cross the placenta and blood-brain barrier and contaminate vaccines and biological products made in fetal bovine serum. Could it be that N. sanguineum puts a brake on human longevity, or that impaired immune function or recurrent Nanobacteremia leads to organ system dysfunction and premature senescence, via the mechanism of Pineal Gland calcification?  Could they be everywhere? Rather, why wouldn’t we assume that they are everywhere in our tissues?


Presentation by Hjelle, J, T,

International Nanobacteria Minisymposium

Kuopio, Finland; 3/8/01

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