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Topical DMPS-Glutathione

DMSA, discussed elsewhere on this site, has been the metal binding agent used during MME therapy. Topical DMPS-Glutathione, developed by Dr. Rashid Buttar, is emerging as an alternative, and for many patients preferable, metal binding agent. The instruction sheet that we made up for our patients is presented below:

TD- DMPSÔ

Target dose: ___ drops to the skin every other day near bedtime
Begin at ___ drops and increase in ___ drop increments as tolerated
Get your daily minerals in by dinner on treatment nights, and not until noon the next day

EDTA, the metal binding agent used in classic chelation therapy, binds avidly to Lead, Cadmium, and several other metals, but it has little activity against Mercury. Stated otherwise, EDTA does a poor job of removing Mercury from your body. DMSA, an oral agent, can bind to all three of the above metals, but only weakly. Our most effective Mercury scavenger is DMPS (2-3-dimercaptopropane-1-sulfonate):

CH₂¾ CH¾ CH₂¾SO₃Na

½ ½

SH SH

Glutathione plays a role in multiple physiologic processes (to liberate one molecule of Nitric Oxide from the sl NTG that you take for angina, one molecule of Glutathione is used up). Glutathione serves as our primary intracellular antioxidant, antioxidant recycler, and detoxifier, and has been demonstrated to be of therapeutic value in certain neurological and cardiovascular conditions. Glutathione can reduce Mercury from its oxidized form, which binds tightly to intracellular structures, to its reduced form, which is easier to mobilize. Co-administration of Glutathione enhances the ability of DMPS to clear Mercury.

The problem with both DMPS and Glutathione, to date, has been their poor oral absorption. IV administration has been required, with its attendant costs and logistical limitations – a problem. To solve this problem, Dr. Rashid Buttar developed TD- DMPSÔ, a 4:1 ratio of Glutathione and DMPS complexed within liposomes, tiny spherules of fat soluble phosphatidylcholine, which are easily absorbed through the skin. Dr. Buttar’s thinking has moved us from IV to a transdermal delivery system for these most effective agents. Both are now absorbed through the skin, enter the circulation, and act as is they were slowly dripped in via the IV route.

TD-DMPSÔ is available through AMT pharmacy (a division of College Pharmacy) in N. Carolina (866)-828-8203, as a compounded prescription. We fax a prescription, alone with your demographic information, to AMT, and they ship the Transdermal DMPS-Glutathione to you. It is your responsibility to re-order this material when your supply runs low. We have no financial relationship with AMT pharmacy. Writing up all these prescriptions and sending out the faxes is simply part or our overhead – so please make it easy for us to help you.

The side-effects of TD-DMPSÔ are typically the side-effects of Mercury detoxification. Many patients feel nothing, while others experience fatigue, irritability, muscle aching, or possibly a transient aggravation of the symptoms that we feel are due to Mercury overload. Minor symptoms can be ignored, but if you feel poorly, simply decrease the dose (such that less Mercury will be mobilized) to a level that you can tolerate. Later try to slowly increase the dose to the target level. As more Mercury is removed, tolerance to treatment typically improves.

We are in no hurry here. Patience is required. At age 50 we are trying to undo 50 years of progressive cellular Mercury overload. We are not going to get the job done in 2 months. Removing 50 years of Mercury is like peeling off the layers of an onion. To monitor progress, periodic challenge studies will be carried out (measuring urine metal levels following the administration of IV chelators), and we will be monitoring your symptomatic status as well.

It is my belief that many of the degenerative, chronic disease states that plague us today are due to, or aggravated by, intracellular heavy metal overload. These toxins bind, nearly irreversibly, to intracellular structures, inactivating them. Mother Nature never anticipated that her children would be exposed to these toxins, so our ability to clear them is limited. For example, it is estimated that, without medical intervention, it takes 20 years for brain Mercury content to fall by 50% following removal of the source of the Mercury. The medical and scientific literature is full of references linking toxic metals like Mercury, Lead, and Cadmium to the diseases of today.

Before beginning a program of metal detoxification, first begin a program of antioxidant and mineral supplementation (a dedicated 6-a-day preparation, 2 tabs with meals); I may recommend other supplements as well, depending on your overall condition. It is critical that you have a chelator in your blood stream when your Mercury Amalgam fillings are removed; coordination between the Doctor and the Dentist is important. Do not take a metal detoxification program if you are pregnant or nursing. Keep up with your mineral supplements, but do not take minerals within 6 hours of a TD-DMPSÔ application (DMPS binds as tightly to Zinc, Copper, and Chromium as it does to Mercury). 5% of patients will experience a rash at the application site. This will resolve on its own; the best approach here is to rotate the application site. If you develop an infection, hold TD-DMPSÔ until the infection resolves. If you feel poorly, lighten up on the dose for awhile and take extra minerals. If that doesn’t work, give us a call during office hours or move up your follow-up appointment. We have found that DMPS and other metal chelators work best within a negative field magnetic environment. For more information on Mercury and negative field magnetic therapy please see heartfixer.com or amri-ohio.com.