Return to HeartFixer Welcome Page

Chronicles of Berberine

DVD One - Berberine in Lipid Management

DVD Two - Berberine in Diabetes Management and Berberine in Inflammation (Part One)

DVD Three - Berberine in Inflammation (Part Two) and Berberine in Cardiovascular Disease

Chronicles of Berberine Bibliography

Lipid Management:

Effects of berberine on lipid profile in subjects with low cardiovascular risk.  Derosa, G. et al. Expert Opin. Biol. Ther. (2013) 13(4): 475-482.

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity.  Kim, W. eta l. Am J Physiol Endocrinol Metab 296:  E812-E819, 2009.

Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation.  Xiao, H. et al. Pharmacological Reports 2012, 64, 889-895.

Protective Effects of Berberine against Low-Density Lipoprotein (LDL) Oxidation and Oxidized LDL-Induced Cytotoxicity on Endothelial cells.  Hsieh, Y. et al. J. Agric. Food Chem. 2007, 55, 10437-10445.

Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats.  Jia, X. et al. Atherosclerosis.  2008;201(1):101-7.

Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters.  Want, Y. et al. Atherosclerosis.  2010 Mar;209(1):111-17.

Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia.  Wu, N. et al. Am J Physiol Regul Integr Comp Physiol 300:  R635-R643, 2011.

Long-Term Effects of Nutraceuticals (Berberine, Red Yeast Rice, Policosanol) in Elderly Hypercholesterolemic Patients.  Marazzi, G. et al. Adv Ther (2011) 28 (12):1105-1113.

Inhibition of lipid synthesis through activation of AMP kinase:  an additional mechanism for the hypolipidemic effects of berberine.  Brusq, J. et al. Journal of Lipid Research 2006. 47:  1281-1288.

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.  Wong, W. et al. Nature Medicine. Vol. 10, No. 12, Dec. 2004 p. 1344-1351.

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.  Kong, W. et al.  Nat Med.  2004 Dec;10(12):1344-51.

Combination of simvastatin with berberine improves the lipid-lowering efficacy.  Kong, W. et al.  Metabolism.  2008 Aug;57(8):1029-37.

Berberine decreases PCSK9 expression in HepG2 cells. Cameron, J. et al. Atherosclerosis 201 (2008) 266-273.

Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment.  Pisciotta, L. et al.  Lipids in Health and disease.  2012, 11:123

The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet.  Chang, X. et al.  Lipids in Health and Disease 2012, 11:86 pp. 1-8.

Mechanisms of Dysregulation of Low-Density Lipoprotein Receptor Expression in Vascular Smooth Muscle Cells by Inflammatory Cytokines.  Ruan, X. et al. Arterioscler Thromb Vasc Biol. 2006;26:1150-1155.

Cross-talk between TLR4-MyD88-NF-kB and SCAP-SREBP2 pathways mediates macrophage foam cell formation.  Li, L. et al. Am Physiol Heart Circ Physiol 304:  H874-H884, 2013.

Dysregulation of LDL receptor under the influence of inflammatory cytokines:  A new pathway for foam cell formation.  Ruan, X. et al. Kidney International Vol. 60 (2001), pp. 1716-1725.

Berberine decreases PCSK9 expression in HepG2 cells. Cameron, J. et al. Atherosclerosis 201 (2008) 266-273.

Berberine Inhibits the Production of Lysophosphatidylcholine-induced Reactive Oxygen Species and the ERK Pathway in Vascular Smooth Muscle Cells.  Cho, B. et al Mol. Cells, Vol. 20, No. 3, pp. 429-434.

Berberine inhibits NADPH oxidase mediated superoxide production in macrophages.  Sarna, L. et al. Can. J. Physiol. Pharmacol. 88:  369-378 (2010).

Berberine and Its More Biologically Available Derivative Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I.  Turner, N. et al. Diabetes 57:1414-1418, 2008.

Extracellular Signal-Regulated Kinase-Dependent Stabilization of Hepatic Low-Density Lipoprotein Receptor mRNA by Herbal Medicine Berberine.  Abidi, P. et al. Arterioscler Thromb Vasc boil. 2005;25:2170-2176.

Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators:  synthesis, Structure-Activity Relationships, and Cholesterol-Lowering Efficacy.  Li, Y. et al. J. Med. Chem. 2009, 52, 492-501.

Berberine Inhibits the Production of Lysophosphatidylcholine-Induced Reactive Oxygen Species and the ERK Pathway in Vascular Smooth muscle Cells. Cho, B. et al. Molecules and Cells Vol. 20, No. 3, pp. 429-434.

Glucose Management:

Berberine Inhibits Inflammatory Response and Ameliorates Insulin Resistance in Hepatocytes.  Low, T. et al.  Inflammation, Vol. 34, Nos. 6, December 2011 pp. 659-667.

Efficacy of berberine in patients with type 2 diabetes mellitus.  Yin, J. et al.  Metabolism Clinical and Experimental 57 (2008) 712-717.

Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control.  Di Pierro, F. et al. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2012:5 213-217.

Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokine Profile in Human Preadipocytes and Metabolic Syndrome Patients.  Yang, J. et a. Evidence-Based Complementary and Alternative Medicine.  Vol. 2012, Article ID 363845.

A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome.  Affuso, F. et al. World J Cardiol 2012 March 26; 4(3):77-83.

Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor function.  Kong, W. et al.  Metabolism Clinical and Experimental,  58 (2009) 109-119.

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.  Zhang, H. et al. Metabolism Clinical and Experimental 59 (2102) 285-292.

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine.  Zhang, Y. et al. J. Clin. Endocrinol. Metab. 93: 2559-2008.

Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase.  Lie, W. et al. Chin Med J 2008;121(8):706-712.

Inflammation in Obesity is the Common Link Between Defects in Fatty Acid Metabolism and Insulin Resistance.  Steinberg, G.  Cell Cycle 6:8, 888-894, 15 April 2007

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling.  Towler, M, and Hardie, D.  Circ. Res. 2007;100:328-341.

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats.  Zhang, X. et al. PloS One August 2012, Vol. 7, Issue 8, pp. 1-12.

Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism.  Zhang, Q. et al. Evidence-Based Complementary and Alternative Medicine. Vol. 2011, Article ID 924851.

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice.  Xie, W. et al. PloS One September 2011, Vol. 6, Issue 9, pp. 1-10.

Berberine and Its More Biologically Available Derivative Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I.  A Mechanism for the Action of Berberine to activate AMP-Activated Protein Kinase and improve Insulin Action.  Turner, N. et al.  Diabetes 57:1414-1418, 2008.

Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth.  Hsu, Y. et al. Toxicology and Applied Pharmacology  272 (2013) 787-796.

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-kB pathways in diabetic neuropathy.  Yerra, V. et al. Redox Biology 1 (2013) 394-397.

The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients.  Shidfar, F. et al. Iranian Journal of Pharmaceutical Research (2012), 11 (2):  643-652.

Leukocytes from diabetic patients kill retinal endothelial cells:  Effects of Berberine.  Tian, P., et al. Molecular Vision 2013;19:2092-2105.

A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.  Wei, W. et al. European Journal of Endocrinology  (20120166 99-105.

Chronic Effects of Berberine on Blood, Liver Glucolipid Metabolism and Liver PPARs Expression in Diabetic Hyperlipidemic Rats.  Zhou, J. et al. Biol. Pharm. Bull. 31(6) 1169-1176 (2008).

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity.  Kim, W. eta l. Am J Physiol Endocrinol Metab 296:  E812-E819, 2009.

Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults.  Fleischman, A, et al.  Diabetes Care 31:289-294, 2008.

Inflammation and the IKKb/NF-kB axis in obesity- and diet-induced insulin resistance.  Shoelson, S, et al. International Journal of Obesity (2003) 27, S49-S52.

Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKb.  Yi, P. et al. World J Gastroenterol 2008 February 14; 14(6):876-883.

Berberine Inhibits Inflammatory Response and Ameliorates Insulin Resistance in Hepatocytes.  Low, T. et al.  Inflammation, Vol. 34, Nos. 6, December 2011 pp. 659-667.

Inflammation in Obesity is the Common Link Between Defects in Fatty Acid Metabolism and Insulin Resistance.  Steinberg, G.  Cell Cycle 6:8, 888-894, 15 April 2007

Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism.  Zhang, Q. et al. Evidence-Based Complementary and Alternative Medicine. Vol. 2011, Article ID 924851.

Cardiovascular Disease:

Advance of Studies on Anti-atherosclerosis Mechanism of Berberine.  Wu, M. et al. Chin J Integr Med 2010 pr;16(2):188-192.

Berberine-Induced Upregulation of Circulating Endothelial Progenitor cells is Related to Nitric Oxide Production in Healthy Subjects.  Xu, M. et al. Cardiology 2009;112:279-286.

Cardiovascular and metabolic effects of Berberine.  Affuso, F. et al.  World Journal of Cardiology 2010 April 26; 2(4): 71-77.

Effects of berberine on angiotensin-converting enzyme and NO-cGMP system in vessels.  Kang, D. et al. Vascular Pharmacology 39 (2003) 281-286.

Effects of berberine on Regression of Pressure-Overload Induced Cardiac Hypertrophy in Rats. Hong, Y. et al. The American Journal of /Chinese Medicine, Vol. 30, No. 4, 589-599..

Effects of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Huang, C. et al. Thrombosis Research 106 (2002) 223-227.

Vasorelaxant and antiproliferative effects of berberine.  Ko, W. et al. European Journal of Pharmacology 399 (2000) 187-196.

Advance of Studies on Anti-atherosclerosis Mechanism of Berberine.  Wu, M. et al. Chin J Integr Med 2010 pr;16(2):188-192.

Berberine Ameliorates Chronic Kidney Injury Caused by Atherosclerotic Renovascular Disease throught the Suppression of NFkB Signaling Pathway in Rats.  Wan, X. et al. PLOS ONE March 2013, Vol. 8. Issue 3 e59794.

Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy.  Hong, Y. et al. Life Sciences 72 (2003) 2499-2507.

Effect of Berberine on Regression of Pressure-Overload Induced Cardiac Hypertrophy in Rats. Hong, Y. et al. The American Journal of Chinese Medicine, Vol. 30, No. 4, 589-599.

Berberine attenuates cardiac dysfunction in  hyperglycemic and hypercholesterolemic rats.  Dong, S. et al. European Journal of Pharmacology 660 (2011) 368-374.

Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity.  Xu, M. et al Journal of Human Hypertension (2008) 22, 389-93.

Berberine-Induced Upregulation of Circulating Endothelial Progenitor cells is Related to Nitric Oxide Production in Healthy Subjects.  Xu, M. et al. Cardiology 2009;112:279-286.

Berberine-induced upregulation of circulating endothelial progenitor cells is related to nitric oxide production in healthy subjects.  Xu, m. et al.  Cardiology 2009; 112(4):279-86.

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans.  Cheng, F. et al. International Journal of Cardiology 2012 (in press) doi:10.1016/j.ijcard.2012.03.090

Berberine-induced upregulation of circulating endothelial progenitor cells is related to nitric oxide production in healthy subjects.  Xu, m. et al.  Cardiology 2009; 112(4):279-86.

Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study.  Affuso, F. eta l. Nutrition, Metabolism and Cardiovascular Diseases (2010) 20, 656-661.

Effect of Berberine on the mRNA of Nitric Oxide Synthase (NOS) in Rat Corpus Cavernosum.  Yan, T. et al. Journal of Huazhong University of Science and Technology [Med Sci] 25 (2):127-130, 2005.

Activation of AMP-Activated Protein Kinase in Required for Berberine-Induced Reduction of Atherosclerosis in Mice:  The Role of Uncoupling Protein 2. Want, Q. et al. PloS ONE September 2011, Vol. 6, Issue 9, e25436.

Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention.  Meng, S. Clin Exp Pharmacol Physiol.  2012 May;39(5):406-11.

Cardiovascular Effects of Berberine in Patients with Severe Congestive Heart Failure.  Marin-Neto, J. eta l.  Clin. Cardiol. 11, 253-260 (1988).

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.  Zeng, X. et al.  Am J Cardiol. 2003 Jul 15;92(2):173-6.

Berberine behind the thriller of marked symptomatic bradycardia.  Cannillo, M. et al. World Journal of Cardiology 2013 July 26;5(7):261-264.

Berberine alleviates ischemic arrhythmias via recovering depressed Ito and Ica currents in diabetic rats.  Wang, L. et al. Phytomedicine 19 (2012) 206-210.

NADPH Oxidase:  An Update.  Babior, Bernard. Blood, Vol 93, No. 5 (March 1), 1999:  pp. 1464-1476.

Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo.  Berberine improves neointima formation in a rat model.  Lee, S. et al. Atherosclerosis 186 (2006) 29-37.

Inflammation:

Protection by and anti-oxidant mechanism of Berberine against rat liver fibrosis induced by multiple hepatotoxic factors.  Zhang, B. et al. Clinical and Experimental Pharmacology and Physiology (2008) 35, 303-309.

The anti-inflammatory potential of berberine in vitro and in vivo.  Kuo, C. et al. Cancer Letters (2004) 127-137.

Berberine Inhibits Cytosolic Phospholipase A2 and Protects Against LPS-Induced Lung Injury and Lethality Independent of the a2-Adrenergic Receptor in Mice.  Zhang, H. et al. Shock, Vol. 29, No. 5, pp. 617-622, 2008.

BERBERINE REDUCES LEUKOCYTE ADHESION TO LPS-STIMULATED ENDOTHELIAL CELLS AND VCAM-1 EXPRESSION BOTH IN VIVO AND IN VITRO.  Wu, Y. et al.  International Journal of Immunopathology and Pharmacology. Vol. 24, no. 3, 741-750 (2012).

Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice.  Fei, L. et al. Acta Pharmacologica Sinica 2006 Sep;27 (9):1199-1205.

Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoreceptor-independent mechanisms.  Li, H. et al. Acta Pharmacologica Sinica (2011) 32: 1364-1372.

Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides.  Zhang, Q. et al. Food and Chemical Toxicology 49 (2011) 61-69.

Protection by and anti-oxidant mechanism of Berberine against rat liver fibrosis induced by multiple hepatotoxic factors.  Zhang, B. et al. Clinical and Experimental Pharmacology and Physiology (2008) 35, 303-309.

Berberine, a natural product, induces G1-phase call cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells.  Mantena, S. et al. Mol Cancer Ther 2006;5;(2), February 2006.

Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 Cell differentiation in type 1 Diabetic Mice. Cui, G. et al. J Biol Chem. 2009 October 9;284(4):28420-28429.

Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine. Qin, X. et al. The Journal of Immunology

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt dependent mechanism in NSC34 motor neuron-like cells. Hsu, Y. et al. European Journal of Pharmaceutical Sciences 46 (2012) 415-425.

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice.  Mo, C. et al. Antioxid. Redox Signal Vol. 00, No. 00, 2013, pp. 1-15.

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression.  Lv, X. et al. PLOS ONE October 2012 Vol. 7. Issue 10, pp. 1-115.

P13K p55g promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion.  Hu, J. et al. European Journal of Pharmacology 674 (2012) 132-142.

Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells.  Huang, C. et al. Thrombosis Research 106 (2002) 223-227.

Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo.  Berberine improves neointima formation in a rat model.  Lee, S. et al. Atherosclerosis 186 (2006) 29-37.

NF-kB signaling pathway and free radical impact.  Siomek, A.  Acta Biochemica Polonica. Vol. 59, No. 3/2012, pp. 323-331.

Dietary phytochemicals and cancer prevention:  Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Lee, J. et al. Pharmacol Ther. 2013 February 137(2):153-171.

Oxidative stress and gene expression:  The AP-1 and NF-kB connections.  Karin, M. et al. BioFactors 15 (2111) 87-89.

Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress:  implication for atherosclerosis and preeclampsia.  Mann, G. et al. Acta Physiologica Sinica, April 25, 2007, 59 (2):  117-127.

Mechanisms of the Nrf2/Keap1/ARE Signaling System.  Tkachev, V. et al. Biochemistry (Moscow), 2011, Vol. 76, No. 4, pp. 407-422.

Berberine inhibits NADPH oxidase mediated superoxide production in macrophages.  Sarna, L. et al. Can. J. Physiol. Pharmacol. 88:  369-378 (2010).

Berberine protects human proximal tubular cells from hypoxia/ reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways.  Yu, W. et al. Journal of Translational Medicine  2013, 11:24  doi:10.1186/1479-5876-11-24.

Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress:  implication for atherosclerosis and preeclampsia.  Mann, G. et al. Acta Physiologica Sinica, April 25, 2007, 59 (2):  117-127.

Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides.  Zhang, Q. et al. Food and Chemical Toxicology 49 (2011) 61-69.

Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta 1 in patients with lung cancer.  Liu, Y.  European Journal of Cancer 44 (2008) 2425-2432.

Berberine, a natural product, induces G1-phase call cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells.  Mantena, S. et al. Mol Cancer Ther 2006;5;(2), February 2006.

Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor.  Cuh, M. et al. BMC Complimentary and Alternative Medicine 2014, 14:89.